What is the big diet difference between fructose, glucose, sucrose & HFCS, ?

I know sucrose & fructose are both simple sugars but I dont get how theyre actually different. I also dont really understand the dietary significance behind all of these different classifications? Like, I know that complex sugars are worse than simple ones, but I dont really know WHY & even my medical profs in college havent been able to explain it. I'd really like to understand please.

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