URGENT Help!! Genetics!!?
Haemoglobin A is produced in red-blood cell (RBC) precursors but not in neurons. Focusing on regulation of transcription and using what we've learned of gene control, what factors would turn "off" gene expression in neurons, and turn gene expression "on" in RBC precursors?
NOTE: Address the cells as they are right now, you don't have to talk about tissue differentiation (fetal development). Think of it this way: you have two cell types, a gene is off in one of them and on in another, if you could look into the nucleus what would be different between the two cells that explains why the gene is expressed in one and not the other
- jacob sLv 71 month ago
In the RBCs , the chromatin containing the DNA/gene for hemoglobin A in the nucleus is in form of euchromatin and hence is expressed while in neurons the chromatin containing the gene for hemoglobin A is in heterochromatin form and hence hemoglobin gene is not expressed. In other words we can say that hemoglobin A gene is accesible by transcription factors to intiate transcription in RBCs but not in neuron cells.